Bupropion and hydroxybupropion observational pharmacokinetic parameters in plasma and brain ECF after a subcutaneous 10-mg/kg dose of bupropion or a 2-mg/kg dose of hydroxybupropion by the same route
Results for AUC, Cmax, and AUCECF/AUCplasma,u ratio are presented as means (S.E.M.). Results for half-lives are presented as the geometric mean. There were a total of six rats in the bupropion administration group (five for plasma and five for brain), and four rats in the hydroxybupropion administration group.
| Drug | Plasma | Brain ECF | AUCECF/ AUCplasma,u | ||||
|---|---|---|---|---|---|---|---|
| AUC0–∞ | Cmax | Half-Life | AUC0–∞ | Cmax | Half-Life | ||
| nM·min | nM | min | nM·min | nM | min | ||
| Bupropion | 46,205 (5768.6) | 198 (27.1) | 132 | 98,616 (8552.2) | 607 (74.3) | 109 | 2.1 (0.18) |
| Hydroxybupropion (formed) | 2637 (309.8) | 15 (1.8) | 101 | 4249 (225.7) | 23 (1.3) | 94 | 1.8 (0.10) |
| Hydroxybupropion (preformed) | 46,026 (10,737.6) | 496 (145.6) | 50 | 56,683 (5779.6) | 492 (70.8) | 45 | 1.5 (0.21) |