TABLE 1

Pharmacokinetic parameters of rosuvastatin after a single oral dose of 3 mg/kg to male Wistar-Han rats in the presence of vehicle or a single oral dose of FA (250 mg/kg)

Rosuvastatin was administered 0.25 hours after pretreatment with FA. Data are presented as means ± S.D. from three male rats and were derived from noncompartmental analysis.

TreatmentCmaxTmaxt1/2AUC(0–tlast)
ng/mlhhng⋅h/ml
Vehicle7.63 ± 3.991.08 ± 1.012.29 ± 1.6315.0 ± 5.80
FA (250 mg/kg)147 ± 54.5a2.92 ± 1.153.52 ± 4.25369 ± 90.0a
  • a t test with Welch's correction of unpaired t test data (variances/S.D. were not equal between groups, P < 0.05).