Pharmacokinetic parameters of rosuvastatin after a single oral dose of 3 mg/kg to male Wistar-Han rats in the presence of vehicle or a single oral dose of FA (250 mg/kg)
Rosuvastatin was administered 0.25 hours after pretreatment with FA. Data are presented as means ± S.D. from three male rats and were derived from noncompartmental analysis.
| Treatment | Cmax | Tmax | t1/2 | AUC(0–tlast) |
|---|---|---|---|---|
| ng/ml | h | h | ng⋅h/ml | |
| Vehicle | 7.63 ± 3.99 | 1.08 ± 1.01 | 2.29 ± 1.63 | 15.0 ± 5.80 |
| FA (250 mg/kg) | 147 ± 54.5a | 2.92 ± 1.15 | 3.52 ± 4.25 | 369 ± 90.0a |
↵a t test with Welch's correction of unpaired t test data (variances/S.D. were not equal between groups, P < 0.05).