TABLE 1

Basal hepatic gene expression in HIV-Tg and WT rats

Values are presented as means ± S.E.M. Results are reported relative to male WT, which was standardized to 1.

Cytokine or Gene	Gender	WT Rats	HIV-Tg Rats
Inflammatory mediators
IL-1β	Male	1 ± 0.1	0.77 ± 0.08
	Female	2.0 ± 0.33^*	1.49 ± 0.14***^,#
IL-6	Male	1 ± 0.07	1.16 ± 0.1
	Female	1.05 ± 0.26	0.9 ± 0.08
iNOS	Male	1 ± 0.18	1.67 ± 0.22
	Female	1.51 ± 0.18	2.71 ± 0.36**^,#
TNF-α	Male	1 ± 0.14	0.92 ± 0.63
	Female	1.14 ± 0.17	1.59 ± 0.13^*^,#
ABC transporters
Abcb1a	Male	1 ± 0.1	1.03 ± 0.17
	Female	3.90 ± 0.84**	4.95 ± 0.95^*
Abcb1b	Male	1 ± 0.22	0.94 ± 0.18
	Female	1.42 ± 0.15**	2.86 ± 0.58***
Abcg2	Male	1 ± 0.14	0.75 ± 0.11
	Female	1.40 ± 0.17	1.28 ± 0.33
Abcc1	Male	1 ± 0.31	0.61 ± 0.12
	Female	1.30 ± 0.51	0.72 ± 0.11
Abcc2	Male	1 ± 0.32	1.34 ± 0.51
	Female	0.73 ± 0.03	2.01 ± 0.73
Abcc3	Male	1 ± 0.15	0.73 ± 0.05
	Female	3.99 ± 0.98***	3.95 ± 0.76^*
Abcc4	Male	1 ± 0.2	1.15 ± 0.18
	Female	1.28 ± 0.31	0.82 ± 0.07
Abcb11	Male	1 ± 0.25	1.05 ± 0.28
	Female	3.69 ± 0.62*	1.69 ± 0.5^##
SLC transporters
Slco1a1	Male	1 ± 0.15	1.4 ± 0.11^#
	Female	0.88 ± 0.13	0.77 ± 0.11***
Slco1a2	Male	1 ± 0.17	1.12 ± 0.11
	Female	1.15 ± 0.27	0.97 ± 0.11
Slco1b2	Male	1 ± 0.04	1.22 ± 0.06
	Female	2.22 ± 0.16^*	2.35 ± 0.14^*
Slc22a1	Male	1 ± 0.04	0.95 ± 0.08
	Female	1.53 ± 0.18***	1.57 ± 0.12^*
Slc29a1	Male	1 ± 0.14	1.27 ± 0.09
	Female	0.92 ± 0.1	0.87 ± 0.07***
Slc10a1	Male	1 ± 0.06	1.07 ± 0.05
	Female	2.14 ± 0.4^*	1.60 ± 0.13**^,#
Metabolic enzymes
Cyp3a2	Male	1 ± 0.21	0.38 ± 0.08^##
	Female	0.004 ± 0.001^*	0.005 ± 0.001**
Cyp3a9	Male	1 ± 0.17	1.08 ± 0.19
	Female	13.55 ± 2.20^*	8.56 ± 1.42^*^,##
Cyp7a1	Male	1 ± 0.17	1.05 ± 0.15
	Female	1.51 ± 0.25	2.28 ± 0.47***
Nuclear receptors
Pxr	Male	1 ± 0.15	1.11 ± 0.11
	Female	0.94 ± 0.17	0.78 ± 0.06**
Car	Male	1 ± 0.17	0.82 ± 0.19
	Female	1.02 ± 0.27	0.55 ± 0.12
Fxr	Male	1 ± 0.12	0.93 ± 0.04
	Female	1.35 ± 0.24	1.43 ± 0.1***

↵* P < 0.05; **P < 0.01; ***P < 0.001; ^#P < 0.05; ^##P < 0.01 (asterisks indicate values that are significantly different from male rats within the same strain, whereas pound signs indicate values that are significantly different from WT within the same gender).