Enzyme Source | Km | Vmax | Vmax | Vmax/Km | Vmax/Km |
---|---|---|---|---|---|
μM | nmol/min per nmol P450 | pmol/min per mg | ml/min per nmol | μl/min per mg | |
P450 form | |||||
Marmoset 4F12 | 40 ± 8 | 7.6 ± 1 | 0.19 | ||
Cynomolgus monkey 4F12 | 5.2 ± 0.7 | 2.9 ± 0.1 | 0.56 | ||
Human 4F12 | 5.9 ± 0.8 | 2.4 ± 0.1 | 0.41 | ||
Microsome | |||||
Marmoset intestine | 18 ± 4 | 797 ± 47 | 44 | ||
Cynomolgus monkey intestine | 54 ± 14 | 1230 ± 103 | 23 | ||
Human intestine | 6.4 ± 0.6 | 124 ± 2 | 19 |