Drug | Genotype | t1/2 | C0 | AUCinf | Clearance | Vss |
---|---|---|---|---|---|---|
h | ng/ml | ng⋅h/ml | ml/h per kg | ml/kg | ||
S-Warfarin | wt/wt | 7.9 ± 0.9 | 452 ± 52 | 3400 ± 138 | 29.4 ± 1.2 | 274 ± 24 |
mut/mut | 15.2 ± 3.2* | 446 ± 117 | 7590 ± 1850* | 13.8 ± 3.6* | 272 ± 34 | |
R-Warfarin | wt/wt | 11.0 ± 1.1 | 423 ± 42 | 5920 ± 205 | 16.9 ± 0.6 | 246 ± 20 |
mut/mut | 12.7 ± 2.0 | 407 ± 88 | 7240 ± 1180 | 14.1 ± 2.5 | 239 ± 17 |
AUCinf, area under the concentration-time curve from the time of dosing up to infinity with extrapolation of the terminal phase; C0, extrapolated plasma concentration at time 0; mut, mutant; t1/2, half-life; Vss, steady-state volume of distribution; wt, wild type.
↵* P < 0.05 (unpaired t test compared with the wt/wt group).