Summary of the predication accuracy of drug-drug interactions (1/AUC ratio) for the inducers
Six studies (carbamazepine, phenytoin, and phenobarbital) using mRNA and activity data, uncalibrated, calibrated against an Indmax = 8 and calibrated against Indmax=16.
| Activity | mRNA | Activity | mRNA | Activity | mRNA | |
|---|---|---|---|---|---|---|
| Uncalibrated | Uncalibrated | Calibrated (8) | Calibrated (8) | Calibrated (16) | Calibrated (16) | |
| GMFE | 1.39 | 1.44 | 1.68 | 1.46 | 1.49 | 1.35 |
| RMSE | 2.19 | 3.40 | 1.09 | 0.97 | 1.30 | 2.98 |
| % Within acceptance limitsa | 83.3 | 83.3 | 33.3 | 83.3 | 66.7 | 83.3 |
GMFE, geometric mean fold error; RMSE, root mean square error.
↵a Acceptance limits proposed by Guest et al. (2011).