Spearman’s correlation coefficients between expression and methylation
| Gene | Methylation Mark | All Samples | PrenatalLliver | Postnatal Liver |
|---|---|---|---|---|
| CYP3A4 expression | CYP3A4 −383 | −0.48 (P = 0.0001) | −0.21 (P = 0.56) | −0.23 (P = 0.11) |
| CYP3A4 -667 | 0.30 (P = 0.02) | 0.13 (0.73) | −0.07 (P = 0.62) | |
| CYP3A4 -1452 | 0.31 (P = 0.02) | −0.26 (P = 0.47) | 0.02 (P = 0.87) | |
| CYP3A4 -1521 | 0.38 (P = 0.003) | −0.14 (P = 0.70) | 0.12 (P = 0.40) | |
| CYP3A4 -1547 | 0.37 (P = 0.005) | 0.13 (P = 0.73) | 0.03 (P = 0.84) | |
| CYP3A4 −1569 | 0.52 (P < 0.0001) | 0.21 (P = 0.56) | 0.30 (P = 0.04) | |
| CYP3A7 expression | CYP3A7 −182 | −0.35 (P = 0.007) | −0.33 (P = 0.35) | −0.53 (P = 0.0001) |
| CYP3A7 −199 | −0.44 (P = 0.0006) | −0.08 (P = 0.83) | −0.54 (P < 0.0001) | |
| CYP3A7 −219 | −0.44 (P = 0.0006) | −0.26 (P = 0.47) | −0.51 (P = 0.0002) |