Comparison of the Expected Darunavir PK Exposures for Different Regimens per Weight Group.
| Weight Category/Dose | Median C0h (5th-95th percentile) | Median AUC24h (5th-95th percentile) | Median Cmax (5th-95th percentile) |
|---|---|---|---|
| ng/mL | µg.h/mL | ng/mL | |
| 10 to 15 kg | |||
| 30 mg/kg q.d. | 2202 (1337 – 4002) | 77.2 (52.0 – 125) | 5692 (4529 – 7885) |
| 35 mg/kg q.d.a | 2570 (1560 – 4669) | 90 (60.6 – 146) | 6641 (5284 – 9199) |
| 40 mg/kg q.d.b | 2937 (1782 – 5336) | 103 (69.3 – 167) | 7590 (6039 – 10514) |
| 20 mg/kg b.i.d.c | 3270 (2035 – 5772) | 103 (69.3 – 167) | 5557 (4135 – 8234) |
| 15 to 30 kg | |||
| 475 mg q.d. | 1947 (1049 – 4028) | 73.9 (50.0 – 129) | 5545 (4145 – 8224) |
| 550 mg q.d. | 2255 (1214 – 4664) | 85.5 (55.6 – 149) | 6420 (4800 – 9522) |
| 600 mg q.d.b | 2460 (1325 – 5088) | 93.3 (60.6 – 163) | 7004 (5236 – 10388) |
| 375 mg b.i.d.c | 3547 (2028 – 6944) | 117 (75.7 – 203) | 6222 (4335 – 10066) |
| 30 to 40 kg | |||
| 600 mg q.d. | 1826 (1056 – 3556) | 74.5 (51.2 – 120) | 5642 (4455 – 7904) |
| 675 mg q.d.a | 2084 (1190 – 4000) | 83.8 (57.6 – 135) | 6347 (5012 – 8892) |
| 750 mg q.d. | 2316 (1322 – 4445) | 93.1 (64.0 – 150) | 7052 (5569 – 9880) |
| 800 mg q.d.b | 2470 (1410 – 4741) | 99.3 (68.3 – 160) | 7522 (5940 – 10539) |
| 450 mg b.i.d.c | 3329 (2018 – 6021) | 112 (76.8 – 180) | 5963 (4397 – 8932) |
| ≥40 kg | |||
| 800 mg q.d.b | 1920 (1031 – 3948) | 81.1 (53.8 – 137) | 6066 (4615 – 8785) |
| 600 mg b.i.d.c | 3599 (2100 – 6831) | 122 (80.7 – 205) | 6426 (4559 – 10120) |
| Adult | |||
| 800 mg q.d.c | 2041 (911 – 4632) | 87.9 (60.5 – 143) | 6756 (1683)d |