Formation rate of 4-OH-ATX, NDM-ATX, and 2-CH2OH-ATX in NDM-ATX equivalents, stratified by CYP2D6 genotype
Data are from incubations conducted at ATX 3 μM. All experiments conducted in duplicate.
| Pediatric HLM Bank Screen with 3 μM ATX (median and range) | |||
|---|---|---|---|
| CYP2D6 AS (n) | 4'-hydroxy-ATX Formation Rate | N-desmethyl-ATX Formation Rate | 2-methyl-OH-ATX Formation Rate |
| pmol/min/mg | |||
| 0 (10) | 0 (0–0) | 25.1 (18.9–55.0) | 15.4 (5.70–185.0) |
| 0.5 (5) | 89.6 (10.5–328) | 35.4 (18.4–49.2) | 35.6 (13.5–98.7) |
| 1 (34) | 93.3 (6.10–445) | 36.8 (18.0–62.8) | 39.7 (5.8–252) |
| 1.5(20) | 210 (0.5–489.0) | 39.3 (18.1–54.5) | 60.2 (8.70–481) |
| 2+(47) | 186 (0–1540) | 30.3 (15.7–74.2) | 32.2 (5.40–382.5) |