Examples of age-related parameters defining the EH and prior knowledge on their age dependency
Parameter | Definition | Age-Dependency Model |
---|---|---|
QH | Hepatic blood flow as a function of cardiac index | Guyton, 1991 |
MPPGL | Micrograms of microsomal protein per gram of liver | Barter et al., 2008 |
CYP3A4 and CYP1A2 | Picomoles of enzyme abundance | Salem et al., 2014 |
Liver volume | Milliliters of liver | Johnson et al., 2005 |
Albumin and AAG | Plasma proteins concentration (g/l) | Johnson et al., 2006; Sethi et al., 2015 |
AAG, alpha-acid glycoprotein.