TABLE 1

Examples of age-related parameters defining the EH and prior knowledge on their age dependency

ParameterDefinitionAge-Dependency Model
QHHepatic blood flow as a function of cardiac indexGuyton, 1991
MPPGLMicrograms of microsomal protein per gram of liverBarter et al., 2008
CYP3A4 and CYP1A2Picomoles of enzyme abundanceSalem et al., 2014
Liver volumeMilliliters of liverJohnson et al., 2005
Albumin and AAGPlasma proteins concentration (g/l)Johnson et al., 2006; Sethi et al., 2015
  • AAG, alpha-acid glycoprotein.