Immunodetected carboxylesterase (CES) content from postmortem fractionated hepatic samples
Data are given in median pmol/mg protein (interquartile range). Each enzyme is compared across the three donor race/ethnicity groups.
| Enzyme | African American (n = 62) | White (n = 79) | Hispanic (n = 16) | Overall P Valuea |
|---|---|---|---|---|
| Microsomal CES 1 | 14.99* (9.62–18.51) | 17.95 (13.60–20.67) | 10.86** (4.33–20.72) | 0.01 |
| Cytosolic CES1 | 13.62* (5.51–16.91) | 15.46 (0.35–19.58) | 11.94 (0–23.21) | 0.155 |
| Microsomal CES2 | 2.79 (2.05–3.98) | 2.99 (2.20–3.93) | 1.79*** (1.52–1.98) | 0.001 |
| Cytosolic CES2 | 1.83 (1.22–2.23) | 1.69 (1.13–2.07) | 1.51 (0–2.12) | 0.23 |
↵a The overall P value was derived from Kruskal-Wallis comparison across the three groups, whereas the asterisk P value designations within the table represent two-way comparisons using the Mann-Whitney U test.
↵* P ≤ 0.05 compared with whites; **P ≤ 0.01 compared with the other two groups; ***P ≤ 0.001 compared with the other two groups