Transporter | Substrate |
---|---|
NTCP | Atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and taurocholate covalently bound drugs |
OATP1A2 | Acebutolol, atenolol, atrasentan, celiprolol, D-penicillamine, deltorphin-II, erythromycin, fexofenadine, imatinib, levofloxacin, lopinavir, methotrexate, microcystin-LR, ouabain, pitavastatin, rosuvastatin, rocuronium, N-methyl quinine, saquinavir, sotalol, thyroxine, talinolol, tebipenem pivoxil, and unaprostone |
OATP1B1 | Atrasentan, atorvastatin, benzylpenicillin, bosentan, caspofungin, cerivastatin, D-penicillamine, enalapril, ezetimibe glucouronide, fexofenadine, fluvastatin, methotrexate, microcystin-LR, olmesartan, ouabain, pitavastatin, phalloidin, pravastatin, repaglinide, rifampicin, rosuvastatin, simvastatin, SN-38, troglitazone-sulfate, temocapril, and valsartan |
OATP1B3 | Atrasentan, amanitin, bosentan, cyclosporin, digoxin, docetaxel, deltorphin-II, D-penicillamine, enalapril, erythromycin, fexofenadine, fluvastatin, imatinib, methotrexate, microcystin, olmesartan, ouabain, paclitaxel, pitavastatin, phalloidin, pravastatin, rifampicin, rosuvastatin, SN-38, telmisartan, and valsartan |
OATP2B1 | Atorvastatin, benzylpenicillin, bosentan, fluvastatin, fexofenadine, glibenclamide, pravastatin, pitavastatin, rosuvastatin, and unaprostone |
OAT2 | Allopurinol, L-ascorbic acid, bumetanide, erythromycin, 5-fluorouracil, methotrexate, paclitaxel, ranitidine, salicylate, tetracycline, taxol, theophylline, and zidovudine |
OCT1 | Acyclovir, azidoprocainamide, berberine, citalopram, cimetidine, cisplatin, famotidine, furamidine, ganciclovir, imatinib, irinotecan, lamivudine, metformin, methoiodide, morphine, oxaliplatin, ondansetron, procainamide, pentamidine, picoplatin, paclitaxel, quinidine, ranitidine, tropisetron, tramadol, and verapamil |
OCT3 | Adefovir, atropine, amantadine, d-amphetamine, cimetidine, clonidine, citalopram, desipramine, diphenhydramine, dizoclipine, etilefrine, granisetron, imipramine, ketamine, lidocaine, Lamivudine, Metformin, Mitoxantrone, Memantine, O-methylisoprenaline, nicotine, phenoxybenzamine, phencyclidine, prazosin, procainamide, quinidine, ranitidine, tropisetron, and verapamil |
P-gp | Amprenavir, atorvastatin, aldosterone, berberine, corticosterone; cimetidine, cyclosporin A, dexamethasone, digoxin, daunorubicin, doxorubicin, debrisoquine, diltiazem, erythromycin, etoposide, fexofenadine, grapafloxacin, hydrocortisone, indinavir, imatinib, irinotecan, lovastatin, losartan, levofloxacin, loperamide, mitoxantrone, morphine, norverapamil, nelfinavir, paclitaxel, pitavastatin, phenytoin, quinidine, rosuvastatin, ritonavir, rhodamine 123, saquinavir, simvastatin, tacrolimus, taxanes, talinolol, terfenadine, verapamil, vinblastine, and vincristine |
BSEP | Fexofenadine, pravastatin, vinblastine |
MRP2 | Acetaminophen glucuronide, carboxydichlorofluorescein, camptothecin, cerivastatin, cisplatin, doxorubicin, etoposide, fexofenadine, glibenclamide, indomethacin, MTX, mitoxantrone, olmesartan, pitavastatin, pravastatin, rifampin conjugates, rosuvastatin, spiramycin, SN-38 glucouronide, vincristine, and valsartan |
BCRP | Albendazole sulfoxide, cerivastatin, ciprofloxacin, daunorubicin, doxorubicin, dirithromycin, erythromycin, epirubicin, genistein, irinotecan, imatinib, lamivudine, methotrexate, MX, norfloxacin, nitrofurantoin, oxfendazole, ofloxacin, pitavastatin, prazosin, pantoprazole, rifampicin, rhodamine 123, rosuvastatin, sulfasalazine, SN-38, testosterone, tamoxifen, topotecan, and zidovudine |
MATE1 | Acyclovir, cephalexin, fexofenadine, gancyclovir, metformin, oxaliplatin |
MRP1 | Adfovir, apicidin, berberine, camptothecins, ciprofloxacin, citalopram, daunorubicin, doxorubicin, difloxacin, etoposide, edatrexate, epirubicin, flutamide, fifloxacin, grepafloxacin, irinotecan, indinavir, idarubicin, methotrexate, pirarubicin, paclitaxel, ritonavir, romidepsin, raltitrexed, SN-38, saquinavir, tomudex, vincristine, and vinblastine |
MRP3 | Acetaminophen glucuronide, etoposide, fexofenadine, MTX, teniposide, and vincristine |
MRP4 | Azidothymidine, lamivudine, methotrexate, PMEA, and stavudine zidovudine |
MRP5 | Adefovir, atorvastatin, 5-flurouracil, methotrexate, PMEA, and rosuvastatin |
MRP6 | Endothelin receptor antagonist BQ-123 |
OSTα/OSTβ | Digoxin |
MTX, methotrexate.