HLM # | CYP2D6 Genotype | Activity Score | M/F‡ | Age | Race§ | Km | Vmax | Clint |
---|---|---|---|---|---|---|---|---|
µM | pmol/min/mg protein | µl/min/mg protein | ||||||
H0033 | *4/*5 | 0 | M | 44 | C | 79.2 | 20.0 | 0.253 |
H0486 | *4/*5 | 0 | F | 49 | C | 59.1* | 4.64* | NA |
H0446 | *4/*41 | 0.5 | M | 21 | C | 5.35 | 30.9 | 5.78 |
H0439 | *1/*4 | 1 | F | 78 | C | 0.930 | 406 | 437 |
H0455 | *1/*4 | 1 | F | 37 | C | 0.945 | 436 | 461 |
H0028 | *2/*3 | 1 | F | 20 | C | 1.32 | 251 | 190 |
H0157 | *2/*4 | 1 | F | 50 | C | 1.33 | 188 | 141 |
H0021 | *1/*4 | 1 | M | 19 | C | 0.737 | 123 | 167 |
H0025 | *1/*4 | 1 | F | 30 | C | 1.07 | 131 | 122 |
H0115 | *2/*4 | 1 | F | 48 | C | 2.40 | 28.0 | 11.7 |
H0138 | *2/*4 | 1 | F | 70 | C | 1.30 | 71.7 | 55.2 |
H0153 | *1/*1 | 2 | F | 63 | C | 1.01 | 352 | 348 |
H0155 | *1/*1 | 2 | M | 46 | H | 1.65 | 360 | 218 |
H0059 | *1/*2 | 2 | M | 9 | C | 1.33 | 791 | 595 |
H0485 | *1/*2 | 2 | M | 10 | C | 1.50 | 479 | 319 |
H0120 | *1/*2 | 2 | F | 57 | C | 1.34 | 141 | 105 |
H0268 | *1/*1 | 2 | M | 0 | C | 1.81 | 417 | 230 |
H0493 | *1/*1 | 2 | F | 64 | C | 1.33 | 289 | 217 |
H0134 | *2/*2 | 2 | F | 61 | C | 4.59 | 252 | 55.0 |
H0099 | *1/*2x2 | 3 | M | 6 | C | 1.71 | 1600 | 936 |
H0289 | *1/*2x2 | 3 | F | 60 | C | 1.94 | 1220 | 629 |
Average | 5.64 | 379 | 262 |