Parameter | Morphine | ||
---|---|---|---|

Initial Estimate | TM | SFM | |

Blood unbound fraction (f_{B}) | 0.654^{a} | 0.654 | 0.654 |

0.634^{b} | |||

Partition coefficient for rapidly perfused tissue (K_{RP}) | 3.69^{c} | 2.05 (47.2)^{d} | 5.03 (38.8)^{d} |

Partition coefficient for poorly perfused tissue (K_{PP}) | 2.37^{c} | 1.03 (42.8)^{d} | 1.16 (60.3)^{d} |

Partition coefficient for adipose tissue (K_{AD}) | 1.08^{c} | 0.796 (23.9)^{d} | 1.63 (20.9)^{d} |

↵

^{a}Method of Doherty et al. (2006), using*f*_{P}= 0.89 and*C*_{B}/*C*_{P}of 1.08 [*f*_{B}=*f*_{P/}(*C*_{B}/*C*_{P})].↵

^{b}Method of Mistry and Houston (1987), using*f*_{P}= 0.85;*C*_{B}/*C*_{P}= 1.34.↵

^{c}Calculated according to the method of Rodgers and Rowland (2006, 2007).↵

^{d}Fitted estimates, with percent CV within parentheses.