TABLE 1

Physiologic volumes and blood flows used for modeling and simulation of rat data

Blood VolumeValueBlood FlowValue
mlml⋅min−1
Total blood volume (VB)a16.2Hepatic artery (QHA)g3.94
Intestinal blood volume (VIB)b1.5Portal vein (QI)g11.7
Serosal blood (Vser,B) = fQ * VIB^g
Enterocyte blood (Ven,B) = (1 − fQ) * VIBRapidly perfused tissue (QHP)f33.3
Intestinal tissue (VI)c2.2Poorly perfused tissue (QPP)f20.4
Serosal tissue (Vser) = fQ * VIAdipose tissue (QAD)f6.3
Enterocyte tissue (Ven) = (1 − fQ) * VI
Liver blood (VLB)d3.24
Liver tissue (VL)e6.59
Rapidly perfused tissue (heart, kidney, lung, brain) (VRP)f15.6
Poorly perfused tissue (muscle, bone, skin) (VPP)f210
Adipose tissue (VAD)f21.2
  • ^ estimated according to value of fQ, obtained from fitting.

  • a Obtained from Davies and Morris (1993).

  • b Obtained from Peters (2008), based on 40% of intestine volume.

  • c Obtained from Peters (2008), based on 60% of intestine volume.

  • d Obtained from Everett et al. (1956), based on liver weight of 12.1 g, according to Davies and Morris (1993).

  • e Obtained from Gao and Law (2009), based on 60% of organ volume

  • f Obtained from Corley et al. (2005).

  • g Obtained from Gao and Law (2009), based on cardiac output of 89.7 ml·min1 according to Davies and Morris (1993).