TABLE 8

Discrimination between the TM-PBPK and SFM-PBPK models by the MG urine/bile ratio for intraduodenal/intravenous dosing, demonstrating the route-dependent intestinal glucuronidation of M

ModelRatio of MG in Urine/Bile
Intraduodenal DosingIntravenous DosingIntraduodenal/Intravenous Dosing
4h4h4h
Observed0.541^0.2122.55
Compartmental modeling0.4850.4850.4850.4851.01.0
TM-PBPK0.1310.1310.1310.1311.01.0
SFM-PBPK0.4530.4440.1750.1792.592.47
  • ^ not measured.