Probe Substrate | Testosterone | Midazolam | 4-MU | 7-Hydroxycoumarin | ||||
---|---|---|---|---|---|---|---|---|
SD | ZDF | SD | ZDF | SD | ZDF | SD | ZDF | |
Fraction unbound | 0.78 ± 0.08 | 0.88 ± 0.05a | 0.82 ± 0.03 | 0.89 ± 0.04b | 0.92 ± 0.03 | 0.93 ± 0.02 | 1.00c | 1.00c |
Drug | Rosiglitazone | Glibenclamide | Canagliflozin | Troglitazone | ||||
SD | ZDF | SD | ZDF | SD | ZDF | SD | ZDF | |
Fraction unbound | 0.81 ± 0.01 | 0.89 ± 0.04 | 0.73 ± 0.01 | 0.77 ± 0.05 | 0.49 ± 0.03 | 0.65 ± 0.05b | 0.43 ± 0.03 | 0.61 ± 0.06b |