TABLE 1

Tissue-to-blood ratios of radioactivity in selected tissues after oral administration of [¹⁴C]-osimertinib (4 mg/kg) to male partially pigmented rats and male and female albino rats

	Male Partially Pigmented Rats								Male Albino Rats			Female Albino Rats
	0.5 h	1 h	6 h	24 h	2 days	7 days	21 days	60 days	1 h	6 h	24 h	1 h	6 h	24 h
Bile ducts	63.4	56.5	28.7	2.63	1.57	0.39	NC	NC	66.8	27.4	2.99	29.1	19.0	3.25
Blood	1.00	1.00	1.00	1.00	1.00	1.00	1.00	NC	1.00	1.00	1.00	1.00	1.00	1.00
Brain	1.06	2.17	1.85	0.37	0.19	0.22	0.23	NC	1.41	1.80	0.24	2.09	2.25	0.49
Liver	32.6	24.5	13.3	3.23	2.18	1.01	0.41	NC	29.6	17.3	4.47	35.8	18.6	4.60
Lung	14.0	21.3	20.4	3.11	1.24	0.85	0.81	NC	25.2	33.9	3.21	37.3	43.1	6.10
Muscle	0.90	1.68	2.01	0.46	0.38	0.41	0.27	NC	1.95	2.33	0.41	2.51	2.15	0.55
Ovary	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	5.38	14.6	1.94
Pituitary	11.6	10.5	23.8	5.35	2.31	1.22	1.05	NC	14.9	32.9	14.3	12.0	31.9	13.6
Renal cortex	11.7	15.7	22.2	11.4	8.40	4.07	1.06	NC	18.5	26.4	13.9	18.3	15.2	4.69
Renal medulla	3.82	9.30	11.5	2.89	1.89	1.12	0.60	NC	10.6	14.5	2.87	17.5	20.00	3.00
Skin (non-pigmented)	0.640	1.40	2.18	0.578	0.310	0.199	0.147	NC	ND	ND	ND	ND	ND	ND
Skin (pigmented)	1.01	2.10	2.87	3.15	2.02	5.34	0.170	NC	ND	ND	ND	ND	ND	ND
Skin	ND	ND	ND	ND	ND	ND	ND	ND	1.30	2.22	0.49	0.77	1.82	1.18
Spleen	11.1	19.4	22.7	5.38	3.09	2.77	3.40	NC	23.8	26.6	4.07	29.2	32.7	10.8
Testis	0.44	0.77	2.47	1.08	0.77	0.76	0.68	NC	0.58	1.71	0.70	—	—	—
Thyroid	13.9	12.1	10.8	2.63	1.71	1.84	1.27	NC	18.7	20.1	2.94	20.3	15.1	3.16
Uvea and RPE	7.62	15.0	71.9	97.2	173	151	180	NC	3.34	3.72	1.06	2.94	1.39	0.79

NC, not calculable; ND, not done; RPE, retinal pigment epithelium; —, not applicable.