TABLE 2

Pharmacokinetic parameters after intravenous administration of pravastatin (5 mg/kg) to BDC rats and the serum biochemistry parameters predose

The individual TBIL values in the normal and mild HB groups ranged from 0.00 to 0.19 and 0.33 to 0.75 mg/dl, respectively. The C_plasma,1.5h and C_liver,1.5h represent the concentrations of plasma and liver, respectively, collected at 1.5 hours postdose. Data represent the mean ± S.E.M. of three animals.

Parameter	Normal Group	Mild HB Group
AUC (ng⋅h/ml)	1180 ± 159	2380 ± 505
CL_total (ml/h/kg)	4400 ± 699	2310 ± 521
V_d (ml/kg)	840 ± 69	497 ± 77^*
CL_bile (ml/h/kg)	2390 ± 247	661 ± 367^*
CL_non-bile (ml/h/kg)	2020 ± 505	1650 ± 241
Biliary excretion (% of dose)	55.0 ± 4.8	25.5 ± 9.1^*
C_plasma,1.5h (ng/ml)	12.9 ± 7.6	17.9 ± 9.5
C_liver,1.5h (ng/g)	<5 (3.39 ± 0.93)^{^a}	14.3 ± 4.5
C_liver-to-C_plasma ratio	<0.80 ± 0.42 (0.40 ± 0.12)^{^a}	1.2 ± 0.4
Biliary flow rate (ml/h/kg)	5.78 ± 0.46	6.89 ± 0.74
TBIL (mg/dl)	0.09 ± 0.06	0.55 ± 0.12^*
GGT (IU/l)	2.20 ± 0.98	7.14 ± 1.35^*

↵^a The values in parentheses were calculated by extrapolation of standard curves below the lower limit of quantification (5 ng/g).
↵* P < 0.05 versus normal group.