Concentration-time profile of [14C]ombitasvir metabolites in pooled plasma at selected time point across subjects (n = 4)
| Time | Radioactive Concentration (ng equivalent/g) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ombitasvir | M37 | M36 | M25 | M29 | M34 | M26 | M23 | M5 | |
| 2–4 h | 38.2 | 5.7 | 8.5 | 0.0 | 11.4 | 0.0 | 0.0 | 5.7 | 5.1 |
| 4–6 h | 51.4 | 8.6 | 11.8 | 0.0 | 20.4 | 0.0 | 0.0 | 7.5 | 5.4 |
| 6–8 h | 29.2 | 7.5 | 13.2 | 5.5 | 29.4 | 0.0 | 6.0 | 21.0 | 0.0 |
| 8–10 h | 36.3 | 9.4 | 14.3 | 6.3 | 27.9 | 3.1 | 3.9 | 16.7 | 3.1 |
| 12–24 h | 25.5 | 15.9 | 22.1 | 5.8 | 32.7 | 3.9 | 7.7 | 28.4 | 0.0 |
| 24–48 h | 2.5 | 12.1 | 23.0 | 3.4 | 37.9 | 0.0 | 5.3 | 29.8 | 0.0 |
| 48–72 h | 3.4 | 17.6 | 22.7 | 7.8 | 37.3 | 0.0 | 4.4 | 8.8 | 0.0 |
| 72–96 h | 5.5 | 13.5 | 22.6 | 0.0 | 27.7 | 4.4 | 3.3 | 10.9 | 0.0 |
| 96–120 h | 2.1 | 10.8 | 20.0 | 3.1 | 30.1 | 0.0 | 2.6 | 10.4 | 0.0 |
| 120–144 h | 2.6 | 11.2 | 18.1 | 3.0 | 25.0 | 0.0 | 3.3 | 6.6 | 0.0 |
| 144–168 h | 2.2 | 11.3 | 15.9 | 2.7 | 19.3 | 0.0 | 3.2 | 7.8 | 0.0 |
| 168–192 h | 3.8 | 13.6 | 15.3 | 2.7 | 16.4 | 0.0 | 0.0 | 6.5 | 0.0 |