Liquid chromatography-mass spectrometry detection of metabolites in vivo (Sprague-Dawley rat) or in vitro in Sprague-Dawley rat and human microsomes
| Matrix | Metabolites Detected | |||||
|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | M6 | |
| Rat plasma | √ | √ | √ | √ | √ | √ |
| Rat microsomes | √a | √ | √ | |||
| Human microsomes | √a | √ | √ | |||
↵a Cytosolic AO contamination of microsomes produced low levels of M1.