Drug | Metabolite | Tentative Metabolite Identification | m/z | RT (min) | Species |
---|---|---|---|---|---|
Canagliflozin | Parent | 443 | 3.26 | HH | |
A | P + O – 2 H | 457 | 2.71 | RH, HH | |
B | P + glucuronide | 619 | 2.49 | HH | |
C | P + O + sulfate | 539 | 2.29 | RH, HH | |
D | P + O + glucuronide | 635 | 2.04 | HH | |
Glibenclamide | Parent | 494 | 2.76 | RH, HH | |
A | P + O | 510 | 2.57 | RH, HH | |
B | P + O | 510 | 2.36 | RH, HH | |
C | P + O | 510 | 2.31 | RH, HH | |
D | P + O | 510 | 2.28 | RH, HH | |
E | P + O | 510 | 2.24 | RH, HH | |
F | N-dealkylation | 412 | 2.18 | RH, HH | |
Troglitazone | Parent | 440 | 3.14 | RH,HH | |
A | P + O | 456 | 2.89 | RH, HH | |
B | P + sulfate | 520 | 2.47 | RH, HH | |
C | P + glucuronide | 616 | 2.24 | RH, HH | |
D | P + O + sulfate | 536 | 2.14 | RH | |
E | P + O + sulfate | 536 | 2.35 | RH, HH | |
F | P + O + 2H + sulfate | 538 | 2.01 | RH, HH | |
G | P + O + O | 472 | 2.36 | RH, HH | |
Rosiglitazone | Parent | 358 | 2.69 | RH, HH | |
A | P + O | 374 | 2.27 | RH, HH | |
B | N-desmethyl | 344 | 2.36 | RH, HH | |
C | N-desmethyl + O | 360 | 2.00 | RH, HH | |
D | P + O + glucuronide | 550 | 1.92 | RH, HH | |
E | P + O | 374 | 1.97 | RH, HH |
RT, retention time; RH, rat hepatocyte; HH, human hepatocyte.