TABLE 6

Systemic exposure of metabolites M1 and M2 after an i.p. administration of 1 (10 mg/kg) to control rats or rats pretreated with ABT, allopurinol, or allopurinol + ABT

Area under the curve reported as peak area ratio analyte/IS* h, as no authentic metabolite standards were available. Data represent a mean of n = 2 (± S.E.M). Statistical analyses performed using a two-tailed unpaired t test.

MetaboliteControlABTMean Fold over ControlAllopurinolMean Fold over ControlAllopurinol + ABTMean Fold over Control
M15.10 ± 3.7946.3 ± 24.69.113.4 ± 3.982.674.9 ± 1.74**15
M21.20 ± 1.1017.1 ± 11.914n/an/an/an/a
  • * P < 0.05; **P < 0.01.