Percentages of excretory metabolites of dasabuvir in humans (N = 4) after administration of a single 400-mg oral dose of [14C]dasabuvir
| Metabolite | Feces | Urine | Total |
|---|---|---|---|
| 0–216 h | 0–24 h | ||
| Total radioactivity | 94.4 | 2.20a | 96.6 |
| Dasabuvir | 26.2 | 0.03 | 26.2 |
| M1 | 31.5 | 0.85 | 32.4 |
| M2 | 15.2 | 0.3 | 15.5 |
| M3 | ND | 0.19 | 0.19 |
| M4 | ND | 0.12 | 0.12 |
| M5 | 11.1 | 0.12 | 11.2 |
| M6 | ND | 0.02 | 0.02 |
| M7 | ND | 0.38 | 0.38 |
| M8 | 2.05 | ND | 2.05 |
| M9 | 4.91 | ND | 4.91 |
| M10 | 3.37 | ND | 3.37 |
| M11 | ND | 0.03 | 0.03 |
| U1 | ND | 0.01 | 0.01 |
ND, not determined.
↵a Total radioactivity for urine is 0–216 hours.