TABLE 3

Percentages of excretory metabolites of dasabuvir in humans (N = 4) after administration of a single 400-mg oral dose of [14C]dasabuvir

MetaboliteFecesUrineTotal
0–216 h0–24 h
Total radioactivity94.42.20a96.6
Dasabuvir26.20.0326.2
M131.50.8532.4
M215.20.315.5
M3ND0.190.19
M4ND0.120.12
M511.10.1211.2
M6ND0.020.02
M7ND0.380.38
M82.05ND2.05
M94.91ND4.91
M103.37ND3.37
M11ND0.030.03
U1ND0.010.01
  • ND, not determined.

  • a Total radioactivity for urine is 0–216 hours.