TABLE 1

Pharmacokinetic parameters of total radioactivity, dasabuvir, and metabolite M1

Data are presented as means ± S.D.

AnalyteCmaxTmaxAUC0–lastAUC0–∞t1/2
ngEq/g or ng/mlhngEq/g or ng/mlh
Total radioactivity1300 ± 5864 ± 08251 ± 31119959 ± 3414
Dasabuvir658 ± 2524 ± 06260 ± 19306290 ± 19308.4 ± 3.2
M1267 ± 1163.0 ± 1.22230 ± 9482280 ± 9346.2 ± 1.3
  • t1/2, half-life.