TABLE 1

Plasma pharmacokinetic parameters for anti-diabetic drugs in SD and ZDF rats

Rats were given drugs at 1 mg/kg i.v. via femoral vein. Values were derived from plots shown in Fig. 2. Results shown represent mean ± standard deviation from four animals.

Parameters	Canagliflozin		Glibenclamide		Rosiglitazone		Metformin		Troglitazone
Parameters	SD	ZDF	SD	ZDF	SD	ZDF	SD	ZDF	SD	ZDF
AUC (μM*h)	5.4 ± 0.6	8.6 ± 1.6^{^a}	5.1 ± 1.5	10 ± 1.5^{^b}	40 ± 12	32 ± 7	1.9 ± 0.4	1.5 ± 0.2	0.6 ± 0.1	1.1 ± 0.4^{^a}
AUC_inf (μM*h)	5.8 ± 0.7	9.7 ± 1.8^{^a}	5.3 ± 1.6	24 ± 6.3^{^b}	40 ± 12	32 ± 7	1.9 ± 0.4	1.5 ± 0.2	0.6 ± 0.1	1.3 ± 0.6^{^a}
CL (ml/min per kg)	6.5 ± 0.8	4.0 ± 0.8^{^b}	6.8 ± 1.6	1.5 ± 0.5^{^b}	1.2 ± 0.3	1.5 ± 0.3	71 ± 16	90 ± 14	63 ± 10	35 ± 15^{^a}
Vd_ss (l/kg)	3.4 ± 0.3	2.4 ± 0.3^{^b}	2.4 ± 0.2	3.6 ± 0.5^{^b}	0.3 ± 0.0	0.2 ± 0.0	3.4 ± 2.3	3.7 ± 0.7	1.6 ± 0.6	4.7 ± 3.2
t_1/2 (h)	6.2 ± 0.6	7.6 ± 0.5^{^b}	4.8 ± 0.8	31 ± 9^{^b}	2.9 ± 0.2	2.7 ± 0.1	2.6 ± 3.6	1.1 ± 0.4	2.0 ± 1.2	5.6 ± 4.2

AUC, area under the concentration-time curve; AUC_inf, AUC extrapolated from time zero extrapolated to infinity; Vd_ss, volume of distribution at steady state.
↵^a P < 0.05 with Student’s t test.
↵^b P < 0.01 with Student’s t test.