Pharmacokinetic (PK) parameters of VU0409106 after i.v. (1 mg/kg) or i.p. (3 mg/kg) administration of 1 to control rats or rats pretreated with ABT
Data for control and ABT groups represent a mean of n = 2 (± S.E.M.). Data for control (n = 3) and ABT (n = 4) groups represent a mean (± S.D.). Statistical analysis was performed using a two-tailed unpaired t test.
| Compound Dosed and Quantitated | Dose (Route) | PK Parameter | Control | ABT | Mean Fold over Control |
|---|---|---|---|---|---|
| 1 | 1 mg/kg (i.v.) | CL (ml/min/kg) | 53.5 ± 1.12 | 15.3 ± 1.19 ** | 0.29 |
| Vss (liter/kg) | 0.994 ± 0.052 | 0.946 ± 0.005 | 0.95 | ||
| t1/2 (h) | 0.215 ± 0.016 | 0.721 ± 0.061* | 3.4 | ||
| AUC0–inf (h*ng/ml) | 311 ± 6.52 | 1099 ± 85.7 * | 3.5 | ||
| 3 mg/kg (i.p.) | Cmax (ng/ml) | 787 ± 782 | 2453 ± 589 * | 3.1 | |
| AUC0–inf (h*ng/ml) | 482 ± 247 | 3742 ± 970 ** | 7.8 |
AUC, area under the plasma concentration-time curve; CL, plasma clearance; Cmax, maximal plasma concentration; t1/2, half-life (t1/2 = MRT* ln2); Vss , volume of distribution at steady-state.
↵* P < 0.05, **P < 0.01.