Compound Dosed and Quantitated | Dose (Route) | PK Parameter | Control | ABT | Mean Fold over Control |
---|---|---|---|---|---|

1 | 1 mg/kg (i.v.) | CL (ml/min/kg) | 53.5 ± 1.12 | 15.3 ± 1.19 ** | 0.29 |

V_{ss} (liter/kg) | 0.994 ± 0.052 | 0.946 ± 0.005 | 0.95 | ||

t_{1/2} (h) | 0.215 ± 0.016 | 0.721 ± 0.061^{*} | 3.4 | ||

AUC_{0–inf} (h*ng/ml) | 311 ± 6.52 | 1099 ± 85.7 * | 3.5 | ||

3 mg/kg (i.p.) | C_{max} (ng/ml) | 787 ± 782 | 2453 ± 589 * | 3.1 | |

AUC_{0–inf} (h*ng/ml) | 482 ± 247 | 3742 ± 970 ** | 7.8 |

AUC, area under the plasma concentration-time curve; CL, plasma clearance;

*C*_{max}, maximal plasma concentration;*t*_{1/2}, half-life (t_{1/2}= MRT**ln*2);*V*ss , volume of distribution at steady-state.↵*

*P*< 0.05, ***P*< 0.01.