Pharmacokinetic (PK) parameters of metabolites M1, M2, and M4–M6 after i.p. administration of 1 (3 mg/kg) to control rats or rats pretreated with ABT
AUC and Cmax of all metabolites reported as peak area ratio analyte/IS*h and analyte/IS, respectively. Data represent a mean (± S.D.). Statistical analysis performed using a two-tailed unpaired t test.
| PK Parameter | M1 | M2 | M4–M6 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (n = 3) | ABT (n = 4) | Mean Fold over Control | Control (n = 3) | ABT (n = 4) | Mean Fold over Control | Control (n = 3) | ABT (n = 4) | Mean Fold over Control | |
| Cmax | 0.282 ± 0.223 | 2.07 ± 1.74 | 7.3 | 0.038 ± 0.028 | 0.419 ± 0.351 | 11 | 0.400 ± 0.389 | 0.255 ± 0.113 | 0.64 |
| AUC0–inf | 0.432 ± 0.269 | 6.65 ± 6.41 | 15 | 0.109 ± 0.044 | 1.51 ± 1.36 | 14 | 0.280 ± 0.254 | 0.590 ± 0.160 | 2.1 |