TABLE 2

Comparison of kinetic inactivation parameters with published values using similar plated hepatocyte assays

Drug	Internal Assay (HH8004)			Published
Drug	k_inact	K_I	k_inact/K_I	k_inact	K_I	k_inact/K_I
	min⁻¹	µM	ml/minµmol*	min⁻¹	µM	ml/minµmol*
Clarithromycin^a	0.07	5.2	13	0.09	8.1	11
Erythromycin^b	0.08	10.0	8	0.07	11	6
Mibefradil^a	0.21	0.2	1400	0.28	0.2	1400
Troleandomycin^a	0.04	0.1	345	0.08	0.6	133
Verapamil^a	0.02	1.6	13	0.14	1.9	74

↵^a Albaugh et al., 2012.
↵^b McGinnity et al., 2006.