Gene | Polymorphism Assessed | Genotype in HepaRG |
---|---|---|
P450 | CYP2C9*2 | *2/*2 |
CYP2C9*3 | WT/WT | |
CYP2C9*6 | WT/WT | |
CYP2C19*2 | WT/WT | |
CYP2C19*3 | WT/WT | |
CYP2C19*6 | WT/WT | |
CYP2D6*2 | *2/WT | |
CYP2D6*3 | WT/WT | |
CYP2D6*4 | WT/WT | |
CYP2D6*6 | WT/WT | |
CYP2D6*9 | *9/WT | |
CYP3A5*3 | *3/*3 | |
CYP3A5*6 | WT/WT | |
CYP3A5*8 | WT/WT | |
Transporter | OATP1B1*5 | *5/WTa |
OATP1B3 (T334G) | WT/WTa |
ADME, absorption, distribution, metabolism, and excretion; WT, the wildtype allele was observed in HepaRG cells.
↵a Data reported by BioPredic International (Saint-Grégoire, France) on Certificates of Analysis.