TABLE 2

Induction kinetic parameters (Emax and EC50) of ASV, DCV, BCV, and BCV-M1 following incubation with hepatocytes from three individual donors

DrugParameterFold InductionFold Increase
HC3-15HC1-18/HC3-17aHC5-10HC3-15HC1-18/HC3-17aHC5-10
ASVEmax14.216.743.9414.106.683.00
EC50 (µg/ml)1.000.610.581.380.680.78
DCVEmax28.2413.058.2745.3011.9012.80
EC50 (µg/ml)4.321.832.387.641.966.54
BCVEmax6.542.362.446.172.231.64
EC50 (µg/ml)0.200.030.020.460.450.19
BCV-M1Emax9.682.302.749.131.551.62
EC50 (µg/ml)0.390.020.210.580.190.47
  • a Induction of ASV and DCV was evaluated using lot HC1-18 hepatocytes; induction of BCV and BCV-M1 was evaluated using lot HC3-17 hepatocytes.