Concentrations of 1β-OH-DCA and DCA determined in a control urine and a urine sample from a patient treated with carbamazepine
Urine samples were treated using enzymatic hydrolysis with and without chemical solvolysis.
| Urine | Enzymatic Hydrolysis | Enzymatic Hydrolysis followed by Solvolysis | |
|---|---|---|---|
| nM | nM | ||
| Control | 1β-OH-DCA | 406 | 1776 |
| DCA | 2048 | 4823 | |
| Ratio (1β-OH-DCA/DCA) | 0.2 | 0.4 | |
| Patient | 1β-OH-DCA | 1653 | 5235 |
| DCA | 1249 | 1851 | |
| Ratio (1β-OH-DCA/DCA) | 1.3 | 2.8 |