TABLE 2 

Pharmacokinetic variables of clopidogrel, clopidogrel active cis-5-thiol metabolite, clopidogrel carboxylic acid, and clopidogrel acyl-β-d-glucuronide in 10 healthy volunteers after 300 mg (day 1) of clopidogrel, which was ingested 1 hour before pioglitazone

Data are given as median with range.

VariableClopidogrel Phase
ClopidogrelCmax (ng/ml)1.34 (0.67–32.1)
tmax (h)1.5 (0.92–3.0)
t1/2 (h)2.8 (1.5–5.4)
AUC0–13h (ng⋅h/ml)3.97 (1.61–53.9)
Clopidogrel active cis-5-thiol metaboliteCmax (ng/ml)34.7 (15.7–72.6)
tmax (h)0.92 (0.92–1.5)
t1/2 (h)2.9 (1.1–5.9)
AUC0–13h (ng⋅h/ml)39.4 (21.4–85.5)
Clopidogrel carboxylic acidCmax (ng/ml)11,400 (5,640–15,900)
tmax (h)0.92 (0.92–1.5)
t1/2 (h)3.3 (2.5–6.1)
AUC0–13h (ng⋅h/ml)30,900 (16,700–55,600)
Clopidogrel acyl-β-d-glucuronideCmax (ng/ml)4,120 (1,390–6,640)
tmax (h)1.5 (0.92–2.0)
t1/2 (h)3.0 (2.3–4.4)
AUC0–13h (ng⋅h/ml)16,500 (5,330–31,200)