Haplotypes of CYP2W1 constructed for the exonic SNPs detected in this study
The reference haplotype was extracted from the sequence of CYP2W1*1A and is shown as hap1. For the detected haplotypes, identities with the reference sequence are denoted by blanks; capital letters indicate SNPs. Hyphens indicate the absence of a certain haplotype in the studied population. The CYP2W1 alleles are named according to the P450 allele nomenclature database (http://www.cypalleles.ki.se/cyp2w1.htm). —, the corresponding haplotype was absent in the population group.
| Variant ID Amino Acid | v03 Leu56Leu | v11 Ala181Thr | v12 Val196Val | v15 Cys256Cys | v19 Pro345Pro | v20 Gly376Ser | v22 Asp412Asp | v23 Val432Ile | v24 Pro488Leu | No. of Carriers | Frequency | Allele | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Han | Tibetan | Uighur | Han | Tibetan | Uighur | |||||||||||
| hap1 | C | G | G | C | C | G | C | G | C | 36 | 17 | 29 | 0.36 | 0.17 | 0.29 | *1A |
| hap2 | T | 30 | 44 | 47 | 0.3 | 0.44 | 0.47 | *1B | ||||||||
| hap3 | T | A | 2 | 4 | ― | 0.02 | 0.04 | 0 | ||||||||
| hap4 | T | ― | ― | 1 | 0 | 0 | 0.01 | |||||||||
| hap5 | T | ― | 1 | ― | 0 | 0.01 | 0 | |||||||||
| hap6 | T | A | 2 | ― | 7 | 0.02 | 0 | 0.07 | *2 | |||||||
| hap7 | A | 5 | 2 | 2 | 0.05 | 0.02 | 0.02 | *4 | ||||||||
| hap8 | T | 24 | 30 | 13 | 0.24 | 0.3 | 0.13 | *6 | ||||||||
| hap9 | T | T | 1 | ― | ― | 0.01 | 0 | 0 | ||||||||
| hap10 | G | T | ― | 2 | ― | 0 | 0.02 | 0 | ||||||||
| hap11 | A | T | ― | 1 | ― | 0 | 0.01 | 0 | ||||||||
| hap12 | A | T | ― | ― | 1 | 0 | 0 | 0.01 | ||||||||