Reanalysis of the pharmacokinetics of cocaine in the presence and absence of h2E2 from the fits to the data shown in Fig. 3, A and B
The parameter estimates were generated using the program WinNonLin from the models shown in Figure 3, A and B. + Represents the fold increase from the control values; − represents the percent decrease from control values.
| Parameters | Plasma | Brain | ||||
|---|---|---|---|---|---|---|
| Vehicle | h2E2 | Change | Vehicle | h2E2 | Change | |
| AUC (min*ng/ml) | 3,282 | 48,101 | +14.7-fold | 20,162 | 1,219 | -94% |
| t1/2α (minutes) | 0.5 | 3.2 | +6.5-fold | |||
| t1/2β (minutes) | 16.0 | 21.7 | +1.4-fold | |||
| Cl (l/min/kg) | 0.17 | 0.012 | -93% | |||
| Vdss (l/kg) | 3.5 | 0.2 | -94% | |||