TABLE 1

Half-maximal inhibitory concentrations (IC₅₀ values) and maximal inhibitory effects of selected antimalarial compounds for OATP1A2, OCT1, and OCT2

Data represent background corrected IC₅₀ values (mean ± S.D.) from three to four experiments.

Compound	OATP1A2		OCT1		OCT2
Compound	IC₅₀	Maximum Inhibitory Effect	IC₅₀	Maximum Inhibitory Effect	IC₅₀	Maximum Inhibitory Effect
	µM	%	µM	%	µM	%
Quinine	0.7 ± 1.2	94	3.5 ± 7.6	85	5.9 ± 3.2	92
Chloroquine	1.0 ± 1.5	60	12.8 ± 9 1	80	8.9 ± 5.4	87
Mefloquine	6.0 ± 3.4	93	6.6 ± 6.5	70	14.6 ± 5.8	87
Pyrimethamine	—	—	8.5 ±.1.9	88	3.4 ± 1.4	100
Artemisinin	—	—	4.2 ± 5.5	88	—	—