In vivo formation of M11 and M12 in mice given EPA with and without antibiotic or ABT pretreatment.
| Dose Group | AUC0-6h Ratio Relative to EPA | ||
|---|---|---|---|
| EPA | M11 | M12 | |
| Control | 1.000 | 0.260 | 0.107 |
| Ciprofloxacin pretreatment | 1.000 | 0.119 | 0.044 |
| ABT pretreatment | 1.000 | 0.372 | 0.017 |
| AUC0-6h ratio relative to M11 | |||
| Control | 1.000 | 0.411 | |
| Ciprofloxacin pretreatment | 1.000 | 0.372 | |
| ABT pretreatment | 1.000 | 0.045 | |