TABLE 1

Summary of the in vivo bupropion DDI clinical studies used for predictions

Precipitant	Precipitant Dose (Duration)	Precipitant Dose Interval	Bupropion Victim Drug Dose	Bupropion Dose Interval	Observed DDI (AUCR)	Reference
	mg		mg
Carbamazepine	942 (wk)	QD	150	SD	0.10	Ketter et al. (1995)
Cimetidine	800 (1 d)	QD	300	SD	1.05	Kustra et al. (1999)
Efavirenz	600 (15 d)	QD	150	SD	0.45	Robertson et al. (2008)
Nelfinavir	1250 (14 d)	BID	150	SD	0.92	Kirby et al. (2011)
Rifampin	600 (7 d)	QD	150	SD	0.33	Chung et al. (2011)
	600 (10 d)	QD	150	SD	0.33	Loboz et al. (2006)
	600 (10 d)	QD	150	SD	0.52	Kharasch et al. (2008a)
Ritonavir	100 (23 d)	BID	150	SD	0.78	Park et al. (2010)
	200–400 (14 d)	TID	150	SD	0.67	Kirby et al. (2011)
	600 (23 d)	BID	150	SD	0.34	Park et al. (2010)
	200–300 (18 d)	BID	150	SD	0.98	Kharasch et al. (2008b)
	200–300 (3 d)	BID	150	SD	0.84	Kharasch et al. (2008b)
	200 (2 d)	BID	75	SD	1.2	Hesse et al. (2006)
Teriflunomide	14–70 (14 d)	QD	150	SD	0.91	Sheedy et al. (1977)