TABLE 5

Summary of bupropion DDI predictions

	Dose (Duration)	Predicted DDI (AUCR)			Observed DDI (AUCR)
	Dose (Duration)	R3	Net Effect	SimCYP	AUCR Change
	mg
Precipitant
Carbamazepine	942	0.15	0.52	0.54	0.10
Cimetidine	800	0.99	1.0	1.07	1.05
Efavirenz	600	0.09	0.87	0.70	0.45
Nelfinavir	1250	0.21	0.80	0.90	0.92
Rifampin	600	0.12	0.34	0.76	0.33
	600	0.12	0.34	0.68	0.33
	600	0.12	0.34	0.67	0.52
Ritonavir	100	0.20	0.95	0.90	0.78
	400	0.15	0.67	0.79	0.98
	600	0.16	0.75	0.74	0.34
	300	0.16	0.79	0.78	0.67
	300 (3 d)	0.16	0.79	0.89	0.84
	200 (2 d)	0.18	0.90	0.95	1.20
Teriflunomide	14-70	0.94	1.0	0.83	0.91

Prediction error (GMFE)^{^a}		3.45	1.39	1.50
True positives		100	75	88
True negatives		33	67	83
False positives		67	33	17
False negatives		0	25	13

↵^a Percentage of clinical trials that were predicted as false negative, false positive, true negative, or true positive with respect to induction based on the 0.8-fold cutoff criterion.