RESIZESummary of mean Km,app and Vmax (± S.D.) determined from microsomes prepared from livers of the Tg-composite animals treated with vehicle or rifampin (N = 4)
| Treatment | Km,app | Vmax |
|---|---|---|
| µM | nmol/min/mg protein | |
| Tamoxifen to NDM | ||
| Vehicle | 3.8 ± 0.9 | 0.78 ± 0.02 |
| Rifampin | 4.3 ± 1.3 | 2.6 ± 0.8* |
| Tamoxifen to 4OHT | ||
| Vehicle | 7.9 ± 2.8 | 0.84 ± 0.17 |
| Rifampin | 7.8 ± 1.5 | 0.85 ± 0.26 |
| NDM to endoxifen | ||
| Vehicle | 5.9 ± 1.1 | 2.0 ± 0.72 |
| Rifampin | 6.7 ± 1.4 | 1.9 ± 0.64 |
| 4OHT to endoxifen | ||
| Vehicle | 13 ± 3.3 | 0.35 ± 0.10 |
| Rifampin | 9.9 ± 2.8 | 2.6 ± 0.53* |
↵* P < 0.05 relative to vehicle.