TABLE 1

Percentage of inaccuracy, AFE, and RMSE of IVIVE predictions for 11 data sets

System	Number of Compounds Evaluated	Number of Inaccurate Predictions	AFE	RMSE
		(%)
Brown et al. (2007)
Hepatocytes	37	26 (70.3)	4.5	6460.2
Hallifax et al. (2010)
Microsomes	68	53 (77.9)	5.2	3708.6
Hepatocytes	89	60 (67.4)	3.9	3137.7
Ito and Houston, (2005)
Microsomes	52	45 (86.5)	7.9	1337.0
McGinnity et al. (2004)^{^a}
Hepatocytes	44	22 (50.0)	1.4	94.1
Obach (1999)
Microsomes (fu_b and fu_inc)	29	13 (44.8)	2.3	4.9
Microsomes (fu_b)	29	22 (75.9)	4.3	6.8
Microsomes (no binding)	29	13 (44.8)	1.5	4.3
Riley et al. (2005)^{^b}
Microsomes	37	27 (73.0)	3.3	2314.2
Hepatocytes	56	38 (67.9)	3.1	1356.5
Hepatocytes (with serum)	14	14 (100.0)	21.7	2124.3
Sohlenius-Sternbeck et al. (2010)^{^c}
Microsomes (fu_b and fu_inc)	44	70.0	3.8	5.8
Hepatocytes (fu_b and fu_inc)	46	89.0	5.9	8.0
Microsomes (no binding)	44	41.0	0.5	6.1
Hepatocytes (no binding)	46	41.0	0.8	5.4

↵^a CL_int data were evaluated.
↵^b CL_{int, ub, in vivo} data were evaluated.
↵^c Individual values for predictions with well stirred model were not presented, only summary statistics.