TABLE 5

Ratio of AUC in the presence and absence of inhibitor from simulations. Ratio between simulation and traditional SimpH7.4 given in parentheses.

SimulationBufuralolDextromethorphan
ClozapineaAmiodaroneQuinidineParoxetineClozapineaAmiodaroneQuinidineParoxetine
SimpH 7.41.044.432.044.191.146.423.346.93
SimpH 7.4, FI1.06 (1.0)5.50 (1.2)2.40 (1.2)5.00 (1.2)1.21 (1.1)9.61 (1.5)4.47 (1.3)10.21 (1.5)
SimpH 7, FI1.04 (1.0)3.33 (0.8)1.93 (1.0)2.69 (0.6)1.17 (1.0)7.32 (1.1)3.92 (1.2)4.81 (0.7)
  • a AUC ratios for 900 mg of clozapine dose given.