Percentage of highly protein-bound BDDCS class 1 and class 2 drugs that are inaccurate
| System | Number of Highly Protein-Bound Class 1 Drugs | Number of Inaccurate Highly Protein-Bound Class 1 Predictions | Number of Highly Protein-Bound Class 2 Drugs | Number of Inaccurate Highly Protein-Bound Class 2 Predictions |
|---|---|---|---|---|
| (%) | (%) | |||
| Brown et al. (2007) | ||||
| Hepatocytes | 2 | 1 (50.0) | 8 | 7 (87.5) |
| Hallifax et al. (2010) | ||||
| Microsomes | 8 | 6 (75.0) | 10 | 9 (90.0) |
| Hepatocytes | 9 | 9 (100.0) | 20 | 15 (75.0) |
| Obach (1999) | ||||
| Microsomes (fub and fuinc) | 2 | 1 (50.0) | 4 | 4 (100.0) |
| Microsomes (fub) | 2 | 1 (50.0) | 4 | 4 (100.0) |
| Microsomes (no binding) | 2 | 2 (100.0) | 4 | 4 (100.0) |
| Riley et al. (2005) | ||||
| Hepatocytes | 5 | 4 (80.0) | 21 | 17 (81.0) |
| Hepatocytes (serum) | 2 | 2 (100.0) | 6 | 6 (100.0) |