AFE and RMSE of high and low protein-binding BDDCS class 1 and class 2 drugs
| Protein Binding | Class 1 | Class 2 | ||
|---|---|---|---|---|
| AFE | RMSE | AFE | RMSE | |
| Brown et al. (2007) | ||||
| Hepatocytes | ||||
| High | 2.0 | 56.4 | 6.3 | 13,882.7 |
| Low | 3.1 | 307.1 | 10.3 | 229.6 |
| Hallifax et al. (2010) | ||||
| Microsomes | ||||
| High | 7.8 | 10,335.3 | 5.3 | 2671.0 |
| Low | 4.8 | 349.9 | 4.2 | 473.3 |
| Hepatocytes | ||||
| High | 12.1 | 9814.8 | 4.2 | 479.9 |
| Low | 3.3 | 242.7 | 2.9 | 437.0 |
| Obach (1999) | ||||
| Microsomes (fub and fuinc) | ||||
| High | 1.7 | 0.3 | 4.7 | 3.1 |
| Low | 2.0 | 4.9 | 2.3 | 6.7 |
| Microsomes (fub) | ||||
| High | 4.7 | 0.4 | 7.3 | 3.1 |
| Low | 3.6 | 7.3 | 5.2 | 8.6 |
| Microsomes (no binding) | ||||
| High | 13.7 | 1.5 | 7.7 | 6.8 |
| Low | 1.1 | 17.7 | 1.0 | 2.2 |
| Riley et al. (2005) | ||||
| Hepatocytes | ||||
| High | 3.1 | 175.2 | 3.9 | 2175.6 |
| Low | 2.2 | 173.3 | 2.8 | 136.5 |
| Hepatocytes (serum) | ||||
| High | 17.0 | 406.3 | 64.2 | 3232.0 |
| Low | 8.0 | 170.2 | — | — |