Percentage of inaccuracy, AFE, and RMSE of IVIVE predictions for BDDCS class 1 and class 2 drugs
| System | Number of Class 1 Drugs | Number of Inaccurate Class 1 Predictions | AFE | RMSE | Number of Class 2 Drugs | Number of Inaccurate Class 2 Predictions | AFE | RMSE |
|---|---|---|---|---|---|---|---|---|
| % | (%) | |||||||
| Brown et al. (2007) | ||||||||
| Hepatocytes | 24 | 14 (58.3) | 3.0 | 294.5 | 12 | 11 (91.7) | 7.4 | 11,335.9 |
| Hallifax et al. (2010) | ||||||||
| Microsomes | 42 | 30 (71.4) | 5.2 | 4521.7 | 22 | 20 (91.0) | 4.7 | 1834.4 |
| Hepatocytes | 55 | 36 (65.5) | 4.0 | 3976.5 | 30 | 22 (73.3) | 3.7 | 466.1 |
| Ito and Houston (2005) | ||||||||
| Microsomes | 32 | 27 (84.4) | 6.8 | 390.8 | 16 | 15 (93.8) | 11.2 | 2312.3 |
| McGinnity et al. (2004) | ||||||||
| Hepatocytes | 32 | 16 (50.0) | 1.1 | 99.3 | 9 | 5 (55.6) | 3.0 | 90.9 |
| Obach (1999) | ||||||||
| Microsomes (fub and fuinc) | 20 | 7 (35.0) | 1.9 | 4.6 | 9 | 6 (66.6) | 3.2 | 5.4 |
| Microsomes (fub) | 20 | 13 (65.0) | 3.7 | 6.9 | 9 | 9 (100.0) | 6.0 | 6.7 |
| Microsomes (no binding) | 20 | 7 (35.0) | 1.2 | 4.0 | 9 | 6 (66.7) | 2.5 | 4.8 |
| Riley et al. (2005) | ||||||||
| Microsomes | 24 | 16 (66.7) | 2.7 | 2399.1 | 11 | 9 (81.8) | 6.0 | 2298.5 |
| Hepatocytes | 28 | 16 (57.1) | 2.4 | 175.7 | 22 | 18 (81.8) | 3.8 | 2125.8 |
| Hepatocytes (serum) | 8 | 8 (100.0) | 9.6 | 251.0 | 6 | 6 (100.0) | 64.2 | 3232.0 |