Percentage inaccuracy of BDDCS class 1 and class 2 drugs that are highly protein-bound
| System | Number of Inaccurate Class 1 Predictions | Number of Inaccurate Highly Protein-Bound Class 1 Predictions | Number of Inaccurate Class 2 Predictions | Number of Inaccurate Highly Protein-Bound Class 2 Predictions |
|---|---|---|---|---|
| (%) | (%) | |||
| Brown et al. (2007) | ||||
| Hepatocytes | 14 | 1 (7.1) | 11 | 7 (63.6) |
| Hallifax et al. (2010) | ||||
| Microsomes | 30 | 6 (20.0) | 20 | 9 (45.0) |
| Hepatocytes | 36 | 9 (25.0) | 22 | 15 (68.2) |
| Obach (1999) | ||||
| Microsomes (fub and fuinc) | 7 | 1 (14.3) | 6 | 4 (66.6) |
| Microsomes (fub) | 13 | 1 (7.7) | 9 | 4 (44.4) |
| Microsomes (no binding) | 7 | 2 (28.6) | 6 | 4 (66.7) |
| Riley et al. (2005) | ||||
| Hepatocytes | 16 | 4 (25.0) | 18 | 17 (94.4) |
| Hepatocytes (serum) | 8 | 2 (25.0) | 6 | 6 (100.0) |