TABLE 1

List of endogenous compounds of interest in the metabolomics analysis performed in healthy subjects treated with or without probenecid

Peak Number	Identity	Retention Time	Protonated Molecule	Fold Change (Probenecid Treated/Control)
Peak Number	Identity	Retention Time	Protonated Molecule	Plasma	Urine	Urine/Plasma
		min	m/z
1	Taurine	7.32	124.0073	0.9 ± 0.3	0.2 ± 0.1	0.3 ± 0.1
2	U305^{^a}	7.33	206.0100	1.0 ± 0.1	0.3 ± 0.2	0.2 ± 0.2
3	U118^{^a}	7.29	297.9724	0.9 ± 0.3	0.2 ± 0.2	0.2 ± 0.2
4	GCDCA-S	4.28	528.2634	1.9 ± 1.8	0.2 ± 0.3	0.2 ± 0.4
5	Inosine^{^a},^{^b}	5.03	267.0731	5.6 ± 2.0	0.8 ± 0.5	0.13 ± 0.08
6	U172^{^a}	7.28	126.0031	1.0 ± 0.3	0.13 ± 0.06	0.13 ± 0.08
7	U67^{^a}	7.30	271.0036	1.0 ± 0.3	0.12 ± 0.07	0.12 ± 0.06
8	U42^{^a}	7.30	249.0216	1.0 ± 0.4	0.06 ± 0.04	0.06 ± 0.04
9	U682^{^a}	7.28	286.9776	0.9 ± 0.3	0.04 ± 0.05	0.04 ± 0.05