Plasma concentrations, brain concentrations and brain-to-plasma ratio of GDC-0084 following PO administration (25 mg/kg) to CD1 mice
The results are reported as mean ± S.D. (n = 3).
| Time Postdose | Total | Free | ||||
|---|---|---|---|---|---|---|
| Brain | Plasma | Brain-to-Plasma Ratio | Brain | Plasma | Brain-to-Plasma Ratio | |
| hour | µM | µM | µM | µM | ||
| 1 | 4.72 ± 1.07 | 3.39 ± 0.72 | 1.39 ± 0.02 | 0.32 ± 0.07 | 0.76 ± 0.16 | 0.41 ± 0.01 |
| 6 | 2.46 ± 0.30 | 1.80 ± 0.09 | 1.37 ± 0.17 | 0.16 ± 0.02 | 0.41 ± 0.02 | 0.41 ± 0.05 |