Lu AF09535 Metabolite profiling in human plasma, urine, and feces (pooled samples) given as % total radioactivity in individual matrices
Numbers in brackets are % total dose based on 10% recovery in urine and 70% recovery in feces
| Metabolite | Di-hydroxy* | Di-hydroxy* | Tri-hydroxy | Di-hydroxy | Monohydroxy | Lu AF09535 |
|---|---|---|---|---|---|---|
| Rt (min) | 3.4 | 6.2-7.1 | 7.3-13.8 | 14.9, 30.2-32.7 | 42.6 | 48.6 |
| Matrix | % total radioactivity in matrix (%dose) | |||||
| Plasma | 58.4 | 25.7 | 1.4 | 12.8 | 3.7 | N.D. |
| Urine | 16.1 (1.5) | 61.6 (5.8) | 5.4 (0.5) | 9.6 (0.9) | 2.4 (0.2) | N.D. |
| Feces | N.D. | N.D. | 21.1(14.6) | 4.7 (3.2) | 1.6 (1.1) | 0.1 |
| 68.4 (47.2) | ||||||
| % Total dose | 1.5 | 5.8 | 15.1 | 3.2, 48.1 | 1.3 | 0.1 |
↵* Early elution indicates that the detected metabolites may be aglycones or similar fragments. N.D., not detected